Week 5 & 6: Slowing Down…

Jana E -

Good afternoon, all! Not much has happened since my last post, but that’s all part of research! Last week, I got to work on creating the draft of the abstract for my research medical paper on this special moyamoya syndrome. Of course, I’m not doing it without help — both my on site mentor and his senior fellow have been communicating with me on how to go about this paper. I’ve written research papers before, but never an official medical research one, so this is a valuable learning experience for me.

As most research projects do, my research paper is going to have to go back and forth and undergo countless revisions before it’s ready. It’s a grueling and meticulous task, but that’s research, and I want the best end result possible. If I’m planning to do lots of biological research in the future, which I am, I’m going to have to get used to it.

Since there really isn’t much to say about the first draft that I sent them, I’m going to continue last post’s conversations about variables. Last week, I focused on the demographics aspect of it, but this week I’ll share some other variables that are recorded during or after the hospital visit, not on admission like the demographics are. Two of the variables are what side the stenosis is on and what location the stenosis specifically is. As I mentioned before, stenosis is the narrowing of a vessel to the point where blood flow decreases/gets blocked. Wherever the stenosis is is a good indicator of where the moyamoya is, since the vessels are so small and tangled that flow decreases. The specific phenomenon we’ve recognized in our Hispanic female population is a bilateral moyamoya-type in the supraclinoid section of the ICA. That means the stenosis would be on both the right and the left side, and a good amount of the patients we’ve selected have that.

That’s all for now, talk more next week!

Note: The week number was changed to week 6, since week 5 was off for spring break.

Jana El-Gengaihy

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    ethan_f
    Hi Jana! Considering the prevalence of moyamoya disease in East Asian populations and its genetic links, how might your research on bilateral supraclinoid ICA stenosis in Hispanic women with metabolic comorbidities reshape our understanding of moyamoya syndrome pathogenesis, particularly concerning environmental versus genetic influences and the impact of systemic vascular risk factors?
      jana_e
      Thanks for the question! Moyamoya disease isn't even fully understood right now, but you are right in saying that it has genetic links. The moyamoya syndrome that we've observed in Hispanic women is less genetically predisposed and more environmental--lifestyle and diet play a huge role in it, which definitely could help us understand more about the disease vs. the syndrome.
    Braydon Kim
    Hi Jana, Your meticulous approach to variable refinement in moyamoya syndrome research is commendable—especially given the rarity of bilateral supraclinoid ICA stenosis in Hispanic females. How are you accounting for potential confounders, such as genetic predisposition or coexisting conditions, when analyzing stenosis patterns in your cohort?
      jana_e
      Thanks, Braydon! Genetic predisposition is absolutely something we are looking at, which is why every single patient is marked for whether or not they have a family history of stroke, sickle cell anemia, etc. A lot of the conditions that are observed alongside the stenosis, such as type II diabetes, are largely due to unhealthy lifestyle.
    sophia_l
    Hi Jana! This is so exciting that you are able to write your first official medical paper! Since this is your first time writing a medical research paper, what differences have you noticed between writing general research papers and those focused on biological and medical subjects? How are you adjusting your approach as you continue with this project?
      jana_e
      Thanks for the question, Sophia! One big thing I've noticed is a much larger emphasis on numbers, percentages, and data points--which makes sense considering I'm the one collecting the data and introducing an idea, as compared to my previous regular research papers where I drew from preexisting papers and statistics.

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