Radiology’s Blind Spot: The Underreported Role of Imaging in Bartholin Gland Hyperplasia Diagnosis

Jessie Z -

Dear Readers,

This week, I’ve spent most of my time reviewing literature of the papers already published on this topic. As Bartholin gland hyperplasia is exceedingly rare, only around 20 research papers on this disorder have been published. In addition to the rarity of this condition, many of the authors also bring up how Bartholin gland hyperplasia is underreported. There are several reasons for this occurrence. First, the symptoms often overlap with those of other conditions, like cysts or abscesses (both localized collections of fluid or material within the body). The difference is that Bartholin gland hyperplasia involves an abnormal overgrowth of the gland tissue itself, presenting as a solid mass rather than a fluid-filled lesion. Second, although imaging modalities can play a significant role in diagnosing Bartholin gland hyperplasia, radiologic perspectives on this condition are not extensively covered in research or clinical practice. It’s likely that more common conditions are prioritized in radiological studies, leaving hyperplasia as a less explored topic. I noticed while reviewing the literature that almost no paper presented imaging on this condition. A large majority of them only focused on the pathology and histology aspect, examining the tissues under a microscope. Without sufficient clinical and radiological evidence, this disorder can remain under the radar in both diagnostic and treatment guidelines.

With Dr. Tan and her colleagues at Mayo Clinic, I’ve been able to look at some MRIs of Bartholin gland hyperplasia, comparing them to MRIs of Bartholin gland cysts. As one may expect, the difference between the two is extremely noticeable. I’m very grateful to have the opportunity of working with Dr. Tan and her colleagues on writing a research paper that presents both radiology and pathology findings. Hopefully, we can help bring greater awareness to this condition and ease the worries of patients who have the rare condition.

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Comments:

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    bhavitha_s
    Hi Jessie, great post! Wow, 20 papers is not a lot to work with. Just a quick clarifying question: what is the difference between a cyst and an abscess?
    vishruth_p
    Hi Jessie! I know you said there are only 20 papers on the condition, but did any of these cover patterns in the cases reported so far (e.g., age groups, risk factors)?
    jessie_z
    Hi Bhavitha! A cyst is a benign growth of abnormal cells forming a sac, while an abscess is a result of a bacterial infection causing pus accumulation. I hope that helps!
    jessie_z
    Hi Vishi! Yes, there are common patterns such as a proliferation of mucinous acini (fluid-producing cells) while still maintaining a normal duct-to-acinar relationship, meaning the ducts are not disrupted. The ages typically range from 30-50, so there isn't much commonality in age.
    valerie_p
    Hi Jessie! It's great that you're undertaking a project that can shed light on an issue that isn't studied enough. I'm a little confused about the difference between these two. Are both Bartholin gland hyperplasia and cysts equally harmful to the health or is on worse?
    jessie_z
    Hi Valerie, that's a great question. I would say a cyst is worse since it's prone to infection and requires drainage, while hyperplasia has milder symptoms. Hyperplasia can only be removed via surgical excision, but it's not required as it's benign.

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