Chimeric Dream Made Possible

Shreeya D -

Welcome back guys! If you’re new to the blog, welcome! As for this week’s update, I took a deeper dive into a specific treatment method of immunotherapy: CAR-T Therapy. Chimeric Antigen Receptor T-cell (CAR-T) therapy involves reprogramming a patient’s own immune cells, specifically T cells, to recognize and attack cancer cells.


Furthermore, CAR-T therapy follows a specific procedure (Cleveland Clinic, 2022):

1. Collection of T Cells: T cells are extracted from the patient through a process called leukapheresis, where blood is drawn from the vein in the patient’s arm into an apheresis machine, which removes the T cells from the blood and then pumps the rest of the blood back into your body through a different tube.

2. Genetic Modification: The isolated T cells undergo genetic modification to introduce the CAR (Chimeric Antigen Receptor), which is a synthetic receptor designed to recognize cancer-specific antigens.

3. Cell Expansion: The modified T cells are cultured and expanded in the lab until the cells reach a specific amount for therapeutic use. Once the amount is reached, the new cells are frozen until the body is ready to receive them again.

4. Infusion: The expanded and multiplied CAR-T cells are then infused back into the patient’s body, where they can recognize and destroy cancer cells expressing the targeted antigens.


One of the most promising aspects of CAR-T cell therapy is its potential for personalized medicine; its ability to tailor the treatment to a patient’s specific cancer antigens enhances its precision and effectiveness. Researchers are also hoping to optimize CAR-T therapy, especially by developing next-generation CARs and refining patient selection criteria. As transformative therapy evolves in the future, it has the potential to reshape the oncology and immunology landscape and improve outcomes for patients.



Cleveland Clinic. (2022, January 19). CAR T-cell therapy. Cleveland Clinic.

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    Hi Shreeya, after reading your blog and checking out the article you linked, it looks like a pretty groundbreaking therapy. What inspired you to delve deeper into this specific therapy?
    Hi Ms. Bennett, I actually wanted to research on immunotherapy because cancer typically has a really negative connotation, mainly because a lot of people don’t think there is a definite cure to cancer. So, I wanted to explore immunotherapy to see how it compares to chemo and antibiotics and if it has an avenue for growth as a treatment in the near future.

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