Propranolol Blog Post 12
Samyu Y -
This week, I wrapped up all my experiments and started my calculations. I integrated the peaks of each of the four solvents and determined the absolute intensity of them. The following order was established from least soluble to most soluble: water, dmso, ethanol, and lastly methanol. Interestingly, this list is in the same order as the list of LogP values which shows that the less polar that the solvent was; the better it was at dissolving the Propranolol. One may notice a contradiction between this week and the last where I said more polar was optimal for dissolving the drug. Alas, I confused myself and thought that a larger LogP value would mean a larger polarity when in reality it stands for lipophilicity meaning a smaller LigP value is more polar and a larger less. However, I went with the Welch’s t-test in order to find out if the solubility difference between the solutions was statistically significant and it took a lot of math to understand the background behind how the test works. But, I managed to run the code and proved that the solvents were more effective at dissolving propranolol than just plain water. That concluded the results portion of my paper just leaving me with the conclusion which I was able to write out by talking about future research in human trials, its significance in lowering prices for the American people, some limitations with the number of solvents tested, and the application in liquid capsule pills which contain the solvent within.